Hydroxypropyl methylcellulose (HPMC) is a semisynthetic, inert, viscoelastic polymer having good filmability and mucoadhesivity. The current aim of our research work is to synthesize a polymeric azo conjugate by using HPMC with phenylalanine and to screen its colon specificity by in vitro release model. HPMC was subjected for synthesizing its azo conjugate by using phenylalanine, sodium nitrite, methanol and conc. hydrochloric acid. The azo polymeric conjugate was evaluated for its color, solubility, Rf value, melting point, IR and 1H NMR spectral analysis. It was further subjected for evaluating its colon targeting property by in-vitro method using rat fecal matter. Our experimental results reveal that the HPMC azo conjugate showed promising colon specificity for a period of 120 minutes in a controlled manner. So it can be used as an excipient for formulating colon targeted drug delivery systems.
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